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SCUTELLARIAE RADIX COMPOUNDS AND USE THEREOF FOR INHIBITING OXIDATIVE PHOSPHORYLATION PATHWAY OF MITOCHONDRIA
SCUTELLARIAE RADIX COMPOUNDS AND USE THEREOF FOR INHIBITING OXIDATIVE PHOSPHORYLATION PATHWAY OF MITOCHONDRIA
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机译:用于抑制线粒体的氧化磷酸化途径的瘢痕疙瘩的基础化合物及其用途
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摘要
Provided are Scutellariae radix compounds and the use thereof for inhibiting the oxidative phosphorylation pathway of mitochondria. Specifically provided is the use of a compound of formula I, or an optical isomer thereof, or a racemate thereof, or a solvate thereof, or a pharmaceutically acceptable salt thereof in the preparation of a composition or a preparation. The composition or the preparation is used for one or more uses selected from the group consisting of: (a) inhibiting the oxidative phosphorylation pathway of mitochondria; (b) preventing and/or treating diseases associated with the oxidative phosphorylation pathway of mitochondria; and (c) preventing and/or treating cancers. The compounds can be used for inhibiting the oxidative phosphorylation pathway of mitochondria and preventing and/or treating diseases associated with the oxidative phosphorylation pathway of mitochondria, and especially have a significant inhibitory effect on the upregulation of the oxidative phosphorylation pathway of mitochondria or tumor cells with a low mPTP activity.
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