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DOSAGE FORM PROVIDING PROLONGED RELEASE OF TAPENTADOL PHOSPHORIC ACID SALT
DOSAGE FORM PROVIDING PROLONGED RELEASE OF TAPENTADOL PHOSPHORIC ACID SALT
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机译:剂型提供延长释放的塔布纳酚磷酸盐
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摘要
The invention relates to a pharmaceutical dosage form providing prolonged release of Tapentadol, wherein Tapentadol is present in form of a salt with phosphoric acid (orthophosphoric acid), preferably as dihydrogenphosphate salt. The dosage form according to the invention provides improved prolonged release properties, is particularly resistant against ethanol induced dose dumping, and beyond such resistance provides additional safety features with regard to concomitant use of ethanol, e.g. alcoholic beverages.
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