HVEM Recombinant Herpes Simplex Virus Having Expression Cassette Expressing Fused Protein of Cancer Cell-Targeting Domain and Extracellular Damain of HVEM and Use Thereof

摘要

The present invention discloses a recombinant herpes simplex virus having an expression cassette capable of expressing a fusion protein of a cancer cell targeting region and an extracellular domain of HVEM, and uses thereof. When the recombinant HSV infects a target cell, which is a cancer cell, and enters the target cell, the fusion protein adapter is expressed in the cell along with the proliferation of HSV. In the case of being released into the cell or the adapter has a leader sequence, it is also released before the release of virions by cell lysis.The adapter released to the outside of the cell induces infection of HSV virions into surrounding cancer cells expressing a target molecule recognized by the cancer cell targeting region of the adapter or acts to increase infection efficiency.