Method for producing granule containing nuclear particle, granule containing nuclear particle, pharmaceutical composition containing granule containing nuclear particles and pharmaceutical composition

摘要

Problem to be solved: to provide a method of producing granules containing nuclear particles using a general granulation method for obtaining granules. Also, granules containing nuclear particles produced by the manufacturing method are provided. It also provides pharmaceutical compositions and formulations containing granules containing the nuclear particles.In the granulation method according to one embodiment of the present invention, a granulated liquid having a mist diameter (D50) having a particle diameter (D50) or less of the nuclear particle is sprayed to a mixture containing the original and the nuclear particles and granulated. The granulated liquid may be water. The particle diameter (D50) of the nuclear particles may be larger than the particle diameter (D50) of the drug.Diagram