MAMC-MEDIATED BIOMIMETIC NANOPARTICLES

摘要

Biomimetic magnetic nanoparticles comprising MamC.;The present invention provides superparamagnetic biomimetic nanoparticles comprising magnetite, which can be produced using a scalable process. In addition, these nanoparticles exhibit promising properties, since, if functionalized, they can be converted into drug carriers or contrast agents for obtaining clinical images. They can also be used in clinical setting to purge bone marrow, as molecule separators, and/or for environmental applications as biosensors. These nanoparticles, coupled to a drug, can be encapsulated in liposomes, thereby obtaining magnetoliposomes, which can be functionalized for use in the targeted delivery/release of drugs. In addition, mixtures of magnetoliposomes (functionalized or not with a targeting agent) and functionalized biomimetic magnetic nanoparticles or liposomes containing mixtures of functionalized BMNPs and MNPs can be used to combine different treatments, such as, for example, targeted delivery/release of drugs and hyperthermia.