MAMC-MEDIATED BIOMIMETIC NANOPARTICLES

摘要

The present invention relates to supermagnetic biomimetic nanoparticles comprising magnetite, which can be produced using a scalable process. In addition, these nanoparticles exhibit promising properties, since, if functionalised, they can be converted into drug carriers or contrast agents for obtaining clinical images. They can also be used in clinical environments to purge bone marrow, as molecule separators, and/or for environmental applications as biosensors. Said nanoparticles, coupled to a drug, can be encapsulated in liposomes, thereby obtaining magnetoliposomes, which can be functionalised for use in the targeted delivery/release of drugs. In addition, mixtures of magnetoliposomes (functionalised or not with a targeting agent) and functionalised biomimetic magnetic nanoparticles or liposomes containing mixtures of functionalised BMNPs and MNPs can be used to combine different treatments, such as, for example, the targeted delivery/release of drugs and hyperthermia.