GENETIC CASSETTE COMPRISING THE PHT PATHWAY GENES, RECOMBINANT HOST CELLS COMPRISING IT AND THEIR USE IN THE DEGRADATION AND VALORIZATION OF PHTHALATES

摘要

The present invention provides a recombinant genetic cassette which comprises the catabolic genes involved in the pht pathway as well as an SBP-dependent secondary transporter that are essential for microbial phthalate degradation. The invention also relates to recombinant host cells comprising this cassette and are useful for the aerobic or anaerobic biodegradation of phthalates, preferably o-phthalate (PAs), and for the bioconversion of PAs towards the biosynthesis of value-added biodegradable polymers, such as polyhydroxyalkanoates (PHAs), preferably polyhydroxybutyrates (PHBs).