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Genetically modified mice expressing chimeric molecules of the main histocompatibility complex
Genetically modified mice expressing chimeric molecules of the main histocompatibility complex
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机译:表达主要组织相容性复合物的嵌合分子的基因改性小鼠
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摘要
The invention provides genetically modified non-human animals that express a humanized MHC II protein (humanized MHC II α and β polypeptides), as well as embryos, cells, and tissues comprising the same. Also provided are constructs for making said genetically modified animals and methods of making the same. Methods of using the genetically modified animals to study various aspects of human immune system are provided.
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