首页> 外国专利> Process for the manufacture of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4aR,10aR)-7-hydroxy-1-propyl-1,2,3,4,4a,5,10,10a-octahydrobenzogquinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid

Process for the manufacture of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4aR,10aR)-7-hydroxy-1-propyl-1,2,3,4,4a,5,10,10a-octahydrobenzogquinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid

机译:制造(2S,3S,4S,5R,6S)-3,4,5-三羟基-6 - (((4AR,10AR)-7-羟基-1-丙基-1,2,3,4 ,4a,5,10,10a-octahytrobenzo [g]喹啉-6-基)氧基)四氢-2h-吡喃-2-羧酸

摘要

The present invention relates to a process for manufacturing (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4aR,10aR)-7-hydroxy-1-propyl-1,2,3,4,4a,5,10,10a-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid with the formula (Id) below and salts thereof; ;The compound of formula (Id) is a prodrug of a catecholamine for use in treatment of neurodegenerative diseases and disorders such as Parkinson's Disease.;The invention also relates to new intermediates of said process.
机译:本发明涉及制造方法(2S,3S,4S,5R,6S)-3,4,5-三羟基-6 - (((4AR,10AR)-7-羟基-1-丙基-1,2 ,3,4,4A,5,10,10a-octaHyzoBenzo [g]喹啉-6-基)氧基)四氢-2H-吡喃-2-羧酸,其配方(ID)及其盐; ;式(ID)化合物是用于治疗神经变性疾病和诸如帕金森病等疾病的儿茶酚胺的前药。本发明还涉及所述方法的新中间体。

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