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Method and apparatus for ultrasensitive quantification of microRNA using an atomic force microscope and a hybrid binding domain
Method and apparatus for ultrasensitive quantification of microRNA using an atomic force microscope and a hybrid binding domain
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机译:使用原子力显微镜和混合结合结构域的微小荷纳超敏感定量的方法和装置
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摘要
The present invention provides an apparatus and a method for detecting the presence of and/or determining the amount of a label-free microRNA using an atomic force microscope. The method is extremely selective and/or ultrasensitive. In particular, the present invention provides a cantilever comprising a probe that selectively binds to a double strand of DNA/RNA hybrid complex. The probe comprises a hybrid binding domain (HBD) or a variant thereof.
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