PSD-95 COMBINATION THERAPY WITH PSD-95 INHIBITOR FOR ISCHEMIA

摘要

The present invention provides combination treatments for ischemic diseases that affect or otherwise affect the CNS, eg, stroke. The treatment includes administration of a PSD-95 inhibitor and performing reperfusion therapy (eg, by administration of tPA). Administration of a PSD-95 inhibitor in combination with reperfusion therapy increases the efficacy of reperfusion therapy and/or slows the decline in efficacy of reperfusion therapy over time after the onset of ischemia, thereby opening a window in which reperfusion therapy can be provided. prolong