1-3-tert--1-p--1H--5--3-5--2-1-2--1H--5- CRYSTALLINE FORMS OF 1-3-TERT-BUTYL-1-P-TOLYL-1H-PYRAZOL-5-YL-3-5-FLUORO-2-1-2-HYDROXYETHYL-INDAZOL-5-YLOXYBENZYLUREA HYDROCHLORIDE

摘要

1-(3- tert -Butyl-1-p-tolyl-1H-pyrazol-5-yl)-3-(5-fluoro-2-(1-(2-hydroxyethyl)-1H-indazole Hydrogen chloride salt of-5-yloxy)benzyl)urea, 1-(3- tert -butyl-1-p-tolyl-1H-pyrazol-5-yl)-3-(5-fluoro-2-(1) Crystal form of -(2-hydroxyethyl)-1H-indazol-5-yloxy)benzyl)urea hydrochloride, process for preparing said crystal form, 1-(3- tert -butyl-1-p-tolyl- Crystals of 1H-pyrazol-5-yl)-3-(5-fluoro-2-(1-(2-hydroxyethyl)-1H-indazol-5-yloxy)benzyl)urea hydrochloride Form B Provided herein are pharmaceutical compositions containing the form, methods of making said compositions, pharmaceutical compositions prepared by said methods, and uses of said compositions in the treatment of various diseases and disorders.