首页>
外国专利>
Truncated Chimeric NKG2D Receptors and Ways of Their Application in Immunotherapy Using Natural Killer Cells
Truncated Chimeric NKG2D Receptors and Ways of Their Application in Immunotherapy Using Natural Killer Cells
展开▼
机译:截断的嵌合NKG2D受体和应用在免疫疗法中的应用方法使用天然杀伤细胞
展开▼
页面导航
摘要
著录项
相似文献
摘要
Several embodiments disclosed herein relate to the compositions comprising engineered Natural Killer (NK) cells that express a chimeric receptor, the chimeric receptor imparting to the NK cells an enhanced ability to target specific cells, such as cancerous cells or those affected by an infectious disease. Several embodiments relate to NK cells that target cells expressing natural ligands of NKG2D, where the NK cells comprise transmembrane and/or signaling domains that lead to cytotoxic and/or cytolytic effects when the NK cells bind a target cell. Uses of NK cell compositions to treat diseases are also provided for in several embodiments.
展开▼