An application of a traditional Chinese medicine composition in preparation of drugs for treating or preventing coronavirus infection. The traditional Chinese medicine composition is prepared from the following active pharmaceutical ingredients in parts by weight: 5-15 parts of Cornu Saigae Tataricae or 50-150 parts of goat horns, 10-60 parts of Bulbus Fritillariae Ussuriensis, 15-60 parts of Radix et Rhizoma Rhei, 7-30 parts of Baical Skullcap Root, 7-30 parts of Lapis Chloriti, 10-50 parts of Gypsum Fibrosum, 5-20 parts of Calculus Bovis Artifactus, and 15-60 parts of Radix Glycyrrhizae. The traditional Chinese medicine composition can inhibit intracellular replication of 2019-nCoV, will not pathologically alter infected cells, and can treat or prevent related diseases caused by coronavirus infection.
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