METHODS AND COMPOSITIONS FOR MODULATING ARGININE LEVELS IN IMMUNE CELLS

摘要

Provided are genetically modified T-cells and CAR-T cells that have an increased ability to process the essential amino acid arginine, for example, by overexpressing amino acid transporters, particularly arginine transporters. The genetically modified T-cells and CAR-T cells can survive the often hostile tumor microenvironment better because of their increased ability to process arginine. Also provided are the methods and compositions used to augment the amount of arginine available to a T-cell, thus providing a CAR-T cell that can be effective in the treatment of solid tumors by surviving the tumor microenvironment.