Combination of quinoline-4-carboxamide and benzonaphthridine derivatives as antimalarial agents.

摘要

The present invention comprises 6-fluoro-2 - (4-morpholine-4-yl methyl phenyl) - quinoline-4-carboxylic acid (2-pyrrolidin-1-ethyl ethyl) amide or its prodrug or pharmaceutically acceptable salt This invention relates to a combination of pyrronazidine or its prodrug or pharmaceutically acceptable salt as a second active ingredient.The present invention also includes3 antimalarial active ingredientsThat is,6-fluoro-2 - (4-morpholin-4-yl methyl phenyl) - quinoline-4-carboxylic acid (2-pyrrolidin-1-yl ethyl) - amide or its prodrug or pharmaceutically acceptable saltPyrronazidine or its prodrug or pharmaceutically acceptable saltIt also relates to artemisinin or its combination.The present invention further relates to a pharmaceutical composition comprising such combinations and its use in treatment and / or prevention of malaria.