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Discovery of a quinoline-4-carboxamide derivative with a novel mechanism of action, multistage antimalarial activity, and potent in vivo efficacy

机译：发现具有新型作用机理，多阶段抗疟活性和有效体内功效的喹啉-4-羧酰胺衍生物

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Baragaña Beatriz; Norcross Neil R.; Wilson Caroline; Porzelle Achim; Hallyburton Irene; Grimaldi Raffaella; Osuna-Cabello Maria; Norval Suzanne; Riley Jennifer; Stojanovski Laste; Simeons Frederick R. C.; Wyatt Paul G.; Delves Michael J.; Meister Stephan; Duffy Sandra; Avery Vicky M.; Winzeler Elizabeth A.; Sinden Robert E.; Wittlin Sergio; Frearson Julie A.; Gray David W.; Fairlamb Alan H.; Waterson David; Campbell Simon F.; Willis Paul; Read Kevin D.; Gilbert Ian H.;
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年度 2016
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正文语种 eng
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1. Discovery of a Quinoline-4-carboxamide Derivative with a Novel Mechanism of Action, Multistage Antimalarial Activity, and Potent in Vivo Efficacy [J] . Baragana Beatriz, Norcross Neil R., Wilson Caroline, Journal of Medicinal Chemistry . 2016,第21期

机译：发现具有新型作用机理，多阶段抗疟活性和体内功效强的喹啉-4-羧酰胺衍生物
2. In vivo antimalarial activity and mechanisms of action of 4-nerolidylcatechol derivatives [J] . E Silva, L.F.R.a, c, Antimicrobial agents and chemotherapy. . 2015,第6期

机译：体内抗疟药活性和4-吲哚酰基卡托基衍生物的作用机制
3. Imino-tetrahydro-benzothiazole derivatives as p53 inhibitors: Discovery of a highly potent in vivo inhibitor and its action mechanism [J] . Pietrancosta N, Moumen A, Dono R, Journal of Medicinal Chemistry . 2006,第12期

机译：亚氨基-四氢-苯并噻唑衍生物作为p53抑制剂：发现高效体内抑制剂及其作用机理
4. Design, Synthesis, Biophysical and Structure-Activity Properties of a Novel Dual MDM2 and MDMX Targeting Stapled α-Helical Peptide: ATSP-7041 Exhibits Potent In Vitro and In Vivo Efficacy in Xenograft Models of Human Cancer [C] . V. Guerlavais, K. Darlak, B. Graves American Peptide Symposium . 2013

机译：新型双MDM2和MDMX靶向吻合α-螺旋肽的设计，合成，生物物理和结构 - 活性特性：ATSP-7041在体外表现出效率和体内人类癌症的模型
5. Synthesis of potent analogs of the antimalarial 1,2,4-trioxane natural product artemisinin, and, mechanistic studies directed towards elucidation of the mechanism(s) of antimalarial action of artemisinin and its 1,2,4-trioxane analogs. [D] . Cumming, Jared Nathaniel. 1998

机译：合成抗疟疾的1,2,4-三恶烷天然产物青蒿素的有效类似物，以及旨在阐明青蒿素及其1,2,4-三恶烷类似物的抗疟作用机理的机理研究。
6. Discovery of a Quinoline-4-carboxamideDerivative with a Novel Mechanism of Action Multistage AntimalarialActivity and Potent in Vivo Efficacy [O] . Beatriz Baragaña, Neil R. Norcross, Caroline Wilson, -1

机译：发现喹啉-4-羧酰胺具有新型作用机理的衍生物多阶段抗疟活动和体内功效
7. Discovery of a Quinoline-4-carboxamide Derivative with a Novel Mechanism of Action, Multistage Antimalarial Activity, and Potent in Vivo Efficacy [O] . Baragana, Beatriz, R. Norcross, Neil, Wilson, Caroline, 2016

机译：发现具有新型作用机理，多阶段抗疟活性和体内功效强的喹啉-4-羧酰胺衍生物

Discovery of a quinoline-4-carboxamide derivative with a novel mechanism of action, multistage antimalarial activity, and potent in vivo efficacy

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