COMPOSITIONS AND METHODS FOR AMELIORATING TISSUE INJURY, ENHANCING LIVER REGENERATION AND STEM CELL THERAPIES

摘要

In alternative embodiments, provided are compositions, including pharmaceutical compositions and formulations, products of manufacture and kits, and methods, for: enhancing or accelerating liver regeneration, optionally enhancing or accelerating liver regeneration after tissue injury or liver resection; enhancing or accelerating tissue repair, optionally enhancing or accelerating tissue repair after a trauma, an injury or an infection, wherein optionally the injury is an ischemia-reperfusion injury comprising: administering to an individual in need thereof, a compound or composition capable of inhibiting or decreasing the expression or activity of a matrix metalloproteinase (MMP) in a tissue-specific or tissue-selective manner, in in an end organ specific manner, or administering to the organ, for example, a liver, of an individual in need thereof a compound or composition capable of inhibiting or decreasing the expression or activity of a matrix metallo-proteinase.