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EXPRESSION VECTORS FOR LARGE-SCALE PRODUCTION OF RAAV IN THE BACULOVIRUS/SF9 SYSTEM
EXPRESSION VECTORS FOR LARGE-SCALE PRODUCTION OF RAAV IN THE BACULOVIRUS/SF9 SYSTEM
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机译:Baculovirus / SF9系统中大规模生产的表达载体
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摘要
The present disclosure describes methods and systems for use in the production of adeno-associated virus (AAV) particles, including recombinant adeno-associated virus (rAAV) particles. In certain embodiments, the production process and system use Baculoviral Expression Vectors (BEVs) in the production of AAV particles. In certain embodiments, the production process and system use Spodoptera frugiperda insect cells (such as Sf9 or Sf21) as viral production cells. In certain embodiments, the production process and system use BEVs which lacks a portion or an entirety of the v-cath gene or includes a mutationally inactivated version of the v-cath gene.
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