FULLY HUMAN MONOCLONAL ANTIBODY AGAINST COMPLEMENT C3 MOLECULES AND APPLICATION THEREOF

摘要

Disclosed is a fully human monoclonal antibody against complement C3 molecules. In a CHO cell lysis inhibition experiment, the antibody has a significant effect on inhibiting the lysis of antibody-sensitized CHO cells and red blood cells, and can significantly improve the survival rate of mice in the treatment of mice with MRL/lPr erythema. Also disclosed are a polynucleotide coding the monoclonal antibody, a vector expressing the polynucleotide, a host cell containing the vector, and application of the monoclonal antibody in the preparation of therapeutic drugs for autoimmune diseases.