HUMANIZED SINGLE-CHAIN ANTIBODY OF ANTI-COMPLEMENT C5 MOLECULE AND APPLICATION THEREOF

摘要

Disclosed in the present invention is a humanized single-chain antibody of anti-complement C5 molecule. An equilibrium dissociation constant of the antibody reaches 2.74×10^-11; during the treatment of MRL/lpr lupus erythematosus mice, the anti-C5 single-chain antibody provided by the present invention can significantly improve the viability of mice, symptoms such as the proteinuria, glomerular score, interstitial inflammation, vasculitis, and crescent/necrosis of a treatment group are significantly improved. The anti-C5 single-chain antibody provided by the present invention can be used for preparing drugs for treatment of autoimmune diseases.