METHOD FOR PRODUCING MESENCHYMAL STEM CELLS FOR PREVENTION OR TREATMENT OF BRAIN NEURONAL DISEASES, COMPRISING GHRELIN TREATMENT, AND USE THEREOF

摘要

The present invention relates to a method, comprising ghrelin treatment, for producing mesenchymal stem cells for the prevention or treatment of brain neuronal diseases, a composition for producing mesenchymal stem cells for the prevention or treatment of brain neuronal diseases, mesenchymal stem cells produced by the production method, and a pharmaceutical composition for the prevention or treatment of brain neuronal diseases, comprising the stem cells. When a method for producing mesenchymal stem cells in which an Agouti-related peptide (AgRP) expression level is increased, of the present invention, mesenchymal stem cells produced thereby, or ghrelin is used, various brain neuronal diseases such as Alzheimer's disease can be effectively prevented or treated. In addition, when a composition for producing mesenchymal stem cells in which the AgRP expression level is increased, of the present invention, is used, mesenchymal stem cells in which the AgRP expression level is increased can be effectively produced.