首页> 外文学位 >A movement from traditional malarial chemoprophylaxis to the use of intermittent preventive treatment as a method of protection for children diagnosed with sickle-cell disease: A proposal for consideration based on a systematic review of the literature.
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A movement from traditional malarial chemoprophylaxis to the use of intermittent preventive treatment as a method of protection for children diagnosed with sickle-cell disease: A proposal for consideration based on a systematic review of the literature.

机译:从传统的疟疾化学预防到使用间歇性预防性治疗作为诊断为镰状细胞性疾病的儿童的保护方法的转变:基于文献系统研究的考虑提议。

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摘要

Approximately 200,000 African children are born with sickle-cell anemia each year. Research has shown that individuals with hemoglobin disorders, particularly sickle-cell anemia, have increased susceptibility to contracting malaria. Currently it is recommended that patients diagnosed with sickle-cell anemia undergo malaria chemoprophylaxis in order to decrease their chances of malarial infection. However, studies have shown that routine administration of these drugs increases the risk of drug resistance and could possibly impair the development of naturally acquired immunity. Clinical trials have shown intermittent preventive treatment (IPT) to be an effective method of protection against malaria. The objective of this report was to review previously conducted clinical trials that study the effects of intermittent preventive treatment on malaria and anemia in infants and children. Based on the review, implications for its appropriateness as a protective measure against malaria for infants and children diagnosed with sickle-cell disease were provided.The 18 studies reviewed were randomized controlled trials that focused on IPT's effect on malaria (7 studies), anemia (1 study), or both (8 studies). In addition to these 16, one study looks at IPT's effect on molecular resistance to malaria, and another study is a follow-up to a study in order to review IPT's potential to cause a rebound effect. The 18 th study in this review specifically looks at IPT's protective efficacy in children with SCA. The studies in this report were restricted to randomized controlled trials that have been performed from 2000 to 2010. Reports on anemia were included to illustrate possible added benefits of the use of IPT specific to burdens associated with SCA other than malaria susceptibility. The outcomes of these studies address several issues of concern involving the administration of IPT: protective efficacy (in reference to age, seasonal versus perennial malaria regions, and overall effectiveness against malaria and anemia), drug resistance, drug rebound effect, drug side-effects, and long-term effects. Overall, these showed that IPT has a significant level of protective efficacy against malaria and/or anemia in children. More specifically, the IPT study evaluating children diagnosed with sickle-cell anemia proved IPT to be a more effective method of protection than traditional chemoprophylaxis.
机译:每年大约有20万非洲儿童出生时患有镰状细胞性贫血。研究表明,患有血红蛋白异常(尤其是镰状细胞性贫血)的人对感染疟疾的敏感性增加。当前,建议诊断为镰状细胞性贫血的患者进行疟疾的化学预防,以减少他们感染疟疾的机会。但是,研究表明,常规服用这些药物会增加耐药性的风险,并可能损害自然获得性免疫力的发展。临床试验表明,间歇性预防治疗(IPT)是预防疟疾的有效方法。本报告的目的是回顾先前进行的临床试验,以研究间歇性预防性治疗对婴幼儿疟疾和贫血的影响。在此综述的基础上,提供了将其作为诊断为镰状细胞疾病的婴儿和儿童预防疟疾的适当措施的意义.18篇综述为随机对照试验,重点是IPT对疟疾的影响(7项研究),贫血( 1个研究)或两者(8个研究)。除了这16种,一项研究着眼于IPT对分子抗疟疾的作用,另一项研究是对该研究的后续研究,以复查IPT引起反弹作用的潜力。本评价的第18项研究专门研究了IPT对SCA儿童的保护作用。本报告中的研究仅限于2000年至2010年进行的随机对照试验。其中包括关于贫血的报告,以说明针对疟疾易感性以外与SCA相关的负担使用IPT可能带来的额外好处。这些研究的结果解决了涉及IPT管理的几个令人关注的问题:保护功效(指年龄,季节性与多年生疟疾地区以及对抗疟疾和贫血的总体效力),耐药性,药物反弹作用,药物副作用和长期影响。总体而言,这些表明IPT对儿童的疟疾和/或贫血具有显着水平的保护功效。更具体地说,IPT评估诊断为镰状细胞性贫血的儿童的研究证明,与传统的化学预防相比,IPT是一种更有效的保护方法。

著录项

  • 作者

    Peterson, Courtney L.;

  • 作者单位

    The University of Texas School of Public Health.;

  • 授予单位 The University of Texas School of Public Health.;
  • 学科 Health Sciences Public Health Education.
  • 学位 M.P.H.
  • 年度 2010
  • 页码 49 p.
  • 总页数 49
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

  • 入库时间 2022-08-17 11:37:26

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