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METHODS OF GENERATING AND USING SENESCENT-INDUCED CELLS FOR TREATMENT OF CANCER AND COMPOSITIONS RELATING THERETO
METHODS OF GENERATING AND USING SENESCENT-INDUCED CELLS FOR TREATMENT OF CANCER AND COMPOSITIONS RELATING THERETO
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机译:生成和使用衰老细胞的方法治疗癌症和组合物
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摘要
Compositions and methods for treating cancer in a subject in need thereof is provided. In certain embodiments, the method includes administering therapy-induced senescent (TIS) cells and an immune checkpoint inhibitor to the subject. Also provided are compositions comprising therapy-induced senescent (TIS) cells.
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机译: 本发明涉及(10R)-7-氨基-12-氟-2,10,16-三甲基-5-氧代-10,15,16,17-四氢-2H-8,4-(甲氧基)的丙烯酸形式PYRAZOLO 4,3- H 2,5,11苯并二氮杂四环十二碳-3-羧甲基(洛拉替尼)游离碱(表7)。本发明还涉及包含形式7的药物组合物,以及在哺乳动物中治疗异常细胞生长(例如作为癌症)中使用形式7和这种组合物的方法。