Kir3dl3, anti-hhla2 antibody, and its use as hhla2 receptor

摘要

The present invention is based in part on the discovery of monoclonal antibodies and their antigen binding fragments that bind specifically to hhla2, as well as methods of immunoglobulin, polypeptide, nucleic acids, and methods of using antibodies to diagnose, prognosis and therapeutic purposes.Tmigd2, expressed in naive T cells, is an activation receptor for hhla2 and transmits a costimulatory signal after T cell antigen receptor (TCR) ligation.Tmigd2 is downregulated after repeated TCR stimulation.Diagram