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NON-HUMAN VERTEBRATE COMPRISING HUMAN LIVER CELLS TRANSPLANTED THEREIN AND METHOD FOR PRODUCING THE SAME
NON-HUMAN VERTEBRATE COMPRISING HUMAN LIVER CELLS TRANSPLANTED THEREIN AND METHOD FOR PRODUCING THE SAME
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机译:非人脊椎动物,包括移植物中的人肝细胞及其制造方法
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摘要
This invention provides a non-human vertebrate exhibiting a higher human liver cell growth rate, a higher human liver cell replacement rate, and higher histological-physiological human reproducibility than existing non-human vertebrates comprising the human liver transplanted therein and a method for producing such non-human vertebrate. Specifically, the method for producing a transgenic non-human vertebrate comprising human liver cells transplanted therein comprises transplanting human liver cells in a non-human vertebrate that has impaired or lowered immune reactions against humans in the presence of human IL-6 in vivo.
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