BIOMATERIAL FOR TREATMENT OF ACUTE AND CHRONIC SKIN WOUNDS

摘要

The present invention relates to functionalized biomaterial for skin wound healing, the biomaterial comprising crosslinked hyaluronic acid and hyaluronic acid gel. The crosslinked and gel form hyaluronic acids are preferably mixed in the biomaterial at the v/v ratio of 1:2, and the final glycoprotein content in the biomaterial ir 15-25 µg/ml. The glycoprotein used for fictionalization of the biomaterial has adenosine monophosphate deaminase activity and N-glycans dominating in the purified glycoprotein fractions are oligomannans Man7GlcNAc, Man8GlcNAc, Man9GlcNAc. The in vitro and in vivo data approves the applicability and efficacy of the funcionalized hyaluronic acid based biomaterial in wound healing. The biomaterial can be applied directly to cleaned acute of chronic wounds to promote reepitelization as well as reculater local immune response.