TCR-LIKE ANTIBODY SPECIFIC TO CMV PP65 PEPTIDE/HLA-A*02 COMPLEX, AND USE THEREOF

摘要

The present invention provides a TCR-like antibody or an antigen-binding fragment thereof, the antibody binding to and having specific and improved affinity to an MHC-I molecule, particularly a CMV pp65 peptide complex (CMV_P495-503/HLA-A*02:01) presented by HLA-A*02. The present invention also relates to: a nucleic acid for coding the TCR-like antibody or the antigen-binding fragment thereof according to the present invention; an expression vector comprising the nucleic acid; a cell transformed to the expression vector; a method for producing same; a composition comprising a T cell for expressing the antibody or the antigen-binding fragment thereof as a chimeric antigen receptor; a composition for preventing or treating cancer or an infectious disease; and a composition for diagnosis.