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DNA Damage Repair Inhibitors for Treatment of Cancer
DNA Damage Repair Inhibitors for Treatment of Cancer
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机译:DNA损伤修复抑制剂治疗癌症
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摘要
The present invention relates to the recognition that inhibition of the base excision repair pathway is selectively lethal in cells which are deficient in HR dependent DNA DSB repair. Methods and means relating to the treatment of cancers which are deficient in HR dependent DNA DSB repair using inhibitors which target base excision repair components, such as PARP, is provided herein.
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机译:本发明涉及识别:基础切除修复途径的抑制在缺乏HR依赖性DNA DNA DNB修复的细胞中选择性地致死。 本文提供了使用靶向PARP的抑制剂的HR依赖性DNA DNA DNA DNB修复缺乏的癌症的癌症的方法和方法。
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