Pharmaceutical composition containing lipid complex and pharmaceutical composition containing lipid nanoparticles

摘要

Problem to be solved: to provide a pharmaceutical composition comprising a lipid composition comprising a lipid complex containing a novel double stranded ribonucleic acid to suppress the expression of complement C5, and a pharmaceutical composition comprising lipid nanoparticles containing the double stranded ribonucleic acid.A pharmaceutical composition comprising a lipid complex;Lipid complexContains a double stranded ribo nucleic acid having a combination of sense and antisense chainsCombination of sense and antisense chainsArray number 159 and array numberArray number 141 and array number 142Array number 143 and array number 144Array number 145 and array number 146Array number 147 and array number 148Selected from the group consisting of array number 153 and array number 154Lipid complexCationic lipidLipid neutralEthylene glycol modified lipidContains at least one kind of lipids selected from the group consisting of sterolsPharmaceutical composition.No selection