Targeted thrombolysis for treatment of microvascular thrombosis

摘要

The present invention provides a fusion protein for targeted delivery of plasminogen activator in a fibrin independent manner at the location of the platelet VWF complex or platelet VWF complex.The fusion protein of the present invention is for use in a method of prevention or treatment of a disease or disease associated with such platelet - VWF complex, which may cause microvascular thrombosis in a disease such as thrombotic thrombocytopenic purpura.A preferred targeting factor to incorporate into the fusion protein is, for example, a nanobody for VWF or platelet.Preferred plasminogen activators for use in fusion proteins include the protease domains of uPA or TPA.The present invention further relates to a nucleic acid molecule encoding a fusion protein of the invention, such as a gene therapy vector, and a pharmaceutical composition comprising a fusion protein of the invention or a gene therapy vector thereof.No selection