Manufacturing method of Hwangryunhaedoktang with enhanced antibacterial, anti-inflammatory and antioxidant effects

摘要

The present invention relates to a method for preparing hwangryeonhaedok-tang with enhanced antibacterial, anti-inflammatory and antioxidant effects, comprising the steps of: preparing hwangryeonhaedok-tang comprising extracts of hwangryeon, gold, hwangbaek and gardenia; inoculating the Lactobacillus plantarum strain into the Hwangnyeonhaedoktang; and fermenting after inoculation of the strain. Accordingly, it has antibacterial activity and, in particular, has excellent growth inhibitory activity against Cutibacterium acnes, thereby reducing dermatitis such as acne. In addition, through DPPH radical scavenging activity, ABTS radical scavenging activity, and SOD-like activity, antioxidant activity was increased by 12.3% more than that of non-fermented Hwangryeonhaedoktang. In addition, at a concentration of 400 μg/ml, it has a 43.1% nitric oxide expression inhibitory effect than non-fermented hot water extract Hwangryeonhaedok-tang, and anti-inflammatory by inhibiting the production of intrinsic inflammatory substances (TNF-α, IL-1β and IL-6, etc.) have an effect