HUMAN IGG1 FC REGION VARIANTS AND USES THEREOF

摘要

Polypeptides and related antibodies comprising variant Fc domains are described herein. The variant Fc domain provides a stabilized Fc:Fc interaction when the polypeptide(s), antibody or antibodies bind to its target, antigen or antigens on the surface of a cell, thus improving complement-dependent cytotoxicity (CDC). ) is provided.