Human IgG1 Fc region variants and uses thereof

摘要

#$%^&*AU2020205207A120200730.pdf#####ABSTRACT Described herein are polypeptides and related antibodies comprising a variant Fc domain. The variant Fc domain provide for stabilized Fc:Fc interactions when the polypeptide(s), antibody or antibodies are bound to its target, antigen or antigens on the surface of a cell, thus providing for improved complement-dependent cytotoxicity (CDC).36/36 Figure 32A Clearance t=0 today 21 1000 (D-. 100 10 Ik so* Figure 32B Clearance t=0to day 20 01000 (D U '~E 100, 10 II Qi Z@ z 5p e ~3