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PEPTIDE-CONJUGATED NANOPARTICLES FOR TARGETING, IMAGING, AND TREATMENT OF PROSTATE CANCER
PEPTIDE-CONJUGATED NANOPARTICLES FOR TARGETING, IMAGING, AND TREATMENT OF PROSTATE CANCER
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机译:用于靶向,成像和治疗前列腺癌的肽 - 缀合的纳米颗粒
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摘要
An isolated or a synthetic targeting peptide comprising an amino acid sequence that is at least 90% identical to SEQ ID NO: 8 is disclosed. The targeting peptide may be conjugated to a component selected from the group consisting of polymeric micelles, lipoprotein-based drug carriers, nanoparticle drug carriers, a chemotherapeutic agent, a micelle, a liposome, dendrimers, a polymer, a lipid, an oligonucleotide, a peptide, a polypeptide, a protein, a prostate cancer cell, a stem cell, and an imaging agent. Also disclosed are a kit for imaging and detecting the presence of prostate cancer cells in vivo or in vitro, and a composition for treating prostate cancer, inhibiting prostate cancer cell growth, inducing prostate cancer cell cytotoxicity, and/or increasing the survival rate in a prostate cancer patient.
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机译:含有氨基酸序列的分离的或合成靶向肽,其与SEQ ID NO:8相同的至少90%相同。靶向肽可以与选自聚合物胶束,脂蛋白类药物载体,纳米粒子药物载体,化学治疗剂,胶束,脂质体,树枝状大分子,聚合物,脂质,寡核苷酸,a的组分缀合物。肽,多肽,蛋白质,前列腺癌细胞,干细胞和成像剂。还公开了一种用于成像和检测体内或体外前列腺癌细胞的套件的试剂盒,以及用于治疗前列腺癌的组合物,抑制前列腺癌细胞生长,诱导前列腺癌细胞细胞毒性,以及增加的存活率前列腺癌患者。
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