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PEPTIDE-CONJUGATED NANOPARTICLES FOR TARGETING, IMAGING, AND TREATMENT OF PROSTATE CANCER
PEPTIDE-CONJUGATED NANOPARTICLES FOR TARGETING, IMAGING, AND TREATMENT OF PROSTATE CANCER
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机译:肽缀合的纳米微粒用于前列腺癌的靶向,影像和治疗
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摘要
An isolated or a synthetic targeting peptide comprising an amino acid sequence that is at least 90% identical to SEQ ID NO: 8 is disclosed. The targeting peptide may be conjugated to a component selected from the group consisting of polymeric micelles, lipoprotein-based drug carriers, nanoparticle drug carriers, a chemotherapeutic agent, a micelle, a liposome, dendrimers, a polymer, a lipid, an oligonucleotide, a peptide, a polypeptide, a protein, a prostate cancer cell, a stem cell, and an imaging agent. Also disclosed are a kit for imaging and detecting the presence of prostate cancer cells in vivo or in vitro, and a composition for treating prostate cancer, inhibiting prostate cancer cell growth, inducing prostate cancer cell cytotoxicity, and/or increasing the survival rate in a prostate cancer patient.
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机译:公开了分离的或合成的靶向肽,其包含与SEQ ID NO:8至少90%相同的氨基酸序列。靶向肽可以与选自聚合物胶束,基于脂蛋白的药物载体,纳米颗粒药物载体,化学治疗剂,胶束,脂质体,树状聚合物,聚合物,脂质,寡核苷酸,肽,多肽,蛋白质,前列腺癌细胞,干细胞和显像剂。还公开了用于在体内或体外成像和检测前列腺癌细胞的存在的试剂盒,以及用于治疗前列腺癌,抑制前列腺癌细胞生长,诱导前列腺癌细胞的细胞毒性和/或提高其存活率的组合物。前列腺癌患者。
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