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Multimeric oligonucleotides having decreased kidney clearance
Multimeric oligonucleotides having decreased kidney clearance
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机译:肾脏间隙降低的多聚体寡核苷酸
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摘要
The present invention relates to methods of administering to a subject multimeric oligonucleotides having monomeric subunits joined by linkers. The multimeric oligonucleotides have a molecular weight of at least about 45 kD and other characteristics, such that their clearance due to glomerular filtration is reduced. The present invention also relates to such multimeric oligonucleotides and methods of synthesizing such multimeric oligonucleotides.
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