首页>
外国专利>
Detection of human leukocyte antigen loss of heterozygosity
Detection of human leukocyte antigen loss of heterozygosity
展开▼
机译:杂合性人白细胞抗原丧失的检测
展开▼
页面导航
摘要
著录项
相似文献
摘要
Processes are provided for detecting loss of heterozygosity of Human Leukocyte Antigen (HLA) in a subject using analysis of next generation sequencing (NGS) data. The processes include aligning NGS data and identifying unmapped and mapped reads, updating reference data, and feeding one or more sequence reads to an HLA typing process for identifying candidate HLA alleles and feeding HLA type data to a loss of heterozygosity (LOH) modeling process for determining a LOH status for each HLA allele. A report may be generated of the LOH statuses for each of HLA allele.
展开▼