Triazacyclododecanesulfonamide (TCD) based inhibitor of protein secretion

摘要

Disclosed herein are triazacyclododecanesulfonamide ("TCD") based protein secreting inhibitors such as inhibitors of Sec61, methods of preparation thereof, related pharmaceutical compositions, and methods of using them. For example, the compounds of formula (I) are provided herein.1And a pharmaceutically acceptable salt and composition thereof. The compounds disclosed herein may be used in the treatment of diseases including, for example, inflammation and / or cancer.