Deuterated analogues of ericcro Dahl

摘要

The present invention relates to an exhaust inhibiting compound, a composition, and a method of using the same.More specifically, the present invention includes deuterated analogues of elasto Dahl having excellent pharmacokinetic properties; In cells or compartments protected by the efflux transporter protein such as breast cancer resistance protein (BCRP) and P-glycoprotein (P-gp), it is now possible to facilitate accumulation and partitioning of therapeutic agents into the effective levels.Compartments protected by such transporters include brain, spinal cord, nerve, cerebrospinal fluid, testis, eyeball, retina, inner ear, placenta, mammary gland, liver, biliary tract, kidney, intestines, lungs, adrenal cortex, endometrium, hematopoietic cells, stem cells and solid tumors.In another embodiment, the invention includes a method of using the deuterated analog.No selection