Method and composition comprising cancer suppressor gene therapy and CD122 / CD132 agonist for cancer treatment

摘要

Method and composition for treating cancer in an individualIndividualEffectiveAt least one CD122 / CD132 agonistAt least one immune checkpoint inhibitorAndIncluding administering a viral composition comprising one or more viruses modified to overexpress a tumor suppressor gene and / or an adenoviral death protein;Methods and compositions are provided herein.It is also a method and composition for treating cancer in an individual, an effective amount of at least one tumor decay virus composition, and at least one CD122 / CD132 agonist, to an individual Methods and compositions are also provided herein, including administering at least one immunocheckpoint inhibitor.A method of improving antitumor efficacy by administering the above described active substance in combination with other cancer therapy is also provided herein.In a highly invasive form of cancer, which is commonly known to be resistant to immunotherapy, the treatment has been unexpectedly brought about the remission and healing outcomes of complete tumors.