FLUTAMIDE MICROSPHERE-BASED ARTERIAL EMBOLIZATION FOR TREATING PROSTATE DISORDERS

摘要

This invention provides methods for treating prostate cancer and benign prostatic hyperplasia. Each method comprises introducing biodegradable microspheres into one or more of a subject's prostate arteries, wherein the microspheres (i) have a d90 value from 40 μm to 500 μm; (ii) comprise polylactic acid (PLA) and/or polylactic co-glycolic acid (PLGA); (iii) carry a therapeutically effective amount of pharmaceutical flutamide; (iv) embolize prostate arterial vessels supplied by the one or more arteries into which they are introduced; and (v) release flutamide during embolization. This invention also provides flutamide-carrying biodegradable microspheres and related articles of manufacture.