Heterocyclic inhibitors of ERK1 and ERK2 and their use in cancer therapy

摘要

The present application provides novel heterocyclic compounds and pharmaceutically acceptable salts thereof. Methods for preparing these compounds are also provided. These compounds are useful for inhibiting ERK1 / 2. Administering to a patient in need thereof a therapeutically effective amount of one or more compounds of formula (I), wherein X, Y, Z, J, M, and R1-R8 are defined herein Thus, these compounds are useful for treating conditions associated with dysregulation of the RAS / RAF / MEK / ERK pathway. These compounds can be used to treat a variety of conditions, including those characterized by abnormal cell proliferation. In one embodiment, the disease is cancer.