Arginase inhibition for cancer therapy

摘要

The present invention relates to a method of treating a cancer including a blood tumor and solid tumor.In one embodiment, the method includes impaired arginase activity and / or expression in T cells of a patient with an immune cell, particularly a patient suffering from cancer.Arginase expression may be impaired by RNA interference or by administration of arginase inhibitors by mutations (including deletion or cleavage) of the genes encoding arginase.In a preferred embodiment, T cells are modified within the frame of car (chimeric antigen receptor) therapy.The present invention also provides a treatment method combined with impaired arginase activity and antibody mediated blockade of the negative immune checkpoint regulator (pdl1-pd1 and b7-ctla4 inhibition pathway).