Screening Method of therapeutic agent for metastasis of colorectal cancer

摘要

The present invention relates to a biomarker for predicting metastasis of colorectal cancer and its use, and more specifically, a marker composition for predicting colon cancer metastasis comprising microRNA17-5p (miRNA17-5p), and measuring the expression level of the miRNA It relates to a composition for predicting colon cancer metastasis, a kit for prediction, and a method for predicting colorectal cancer metastasis using the marker. By identifying that the miRNA17-5p according to the present invention directly binds to the 3'UTR of Vimentin, which is an important process of metastasis in colorectal cancer patients, and regulates the expression of Vimentin, a factor related to epithelial mesenchymal transition (EMT), It is expected to be useful as a biomarker for predicting metastasis to organs.