- A controlled release pharmaceutical composition in a monolithic matrix tablet form comprising rebamipide and a process for preparing the same

摘要

The present invention as an active ingredient rebamipide; And it provides a controlled-release pharmaceutical composition in the form of a single matrix tablet for oral administration twice a day containing a combination of a water-soluble saccharide and hypromellose as a release-controlling agent, and a method for preparing the same. The controlled-release pharmaceutical composition of the present invention can be easily prepared through a commonly used tablet manufacturing process, and thus can be easily applied in production. In addition, the controlled-release pharmaceutical composition of the present invention can be formulated to have a size suitable for taking even by elderly patients, thereby increasing patient compliance with the drug.