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COMPOSITIONS AND METHODS FOR THE TREATMENT OF ANESTHESIA-INDUCED NEUROTOXICITY
COMPOSITIONS AND METHODS FOR THE TREATMENT OF ANESTHESIA-INDUCED NEUROTOXICITY
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机译:用于治疗麻醉诱导的神经毒性的组合物和方法
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摘要
A formulation comprising an oligonucleotide selected from the group consisting of an oligonucleotide having one of SEQ ID No.:1 through SEQ ID No.:42 or a variant thereof. Also, a method of treating anesthesia-induced neurotoxicity. The method may comprise administering the formulation. The formulation may be administered prior to, concomitant with, subsequent to, or combinations thereof administration of a general anesthetic comprising a fluorinated compound. The oligonucleotide may be incorporated into a carrier system, for example, a liposome, a biodegradable polymer, a hydrogel, or a cyclodextrin, a nucleic acid complex, a virosome, or combinations thereof. Also, a method of treating anesthesia-induced neurotoxicity.
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机译:包含选自具有寡核苷酸的寡核苷酸的制剂,该寡核苷酸由具有SEQ ID NO.:1至SEQ ID NO.:42的寡核苷酸或其变体。此外,一种治疗麻醉诱导的神经毒性的方法。该方法可包括施用制剂。可在其伴随,或其组合施用包含氟化化合物的一般麻醉剂之前。寡核苷酸可以掺入载体系统中,例如脂质体,可生物降解的聚合物,水凝胶或环糊精,核酸复合物,病毒组或其组合。此外,一种治疗麻醉诱导的神经毒性的方法。
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