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Radical Dosimetry for Analysis of Biopharmaceuticals and Biological Molecules
Radical Dosimetry for Analysis of Biopharmaceuticals and Biological Molecules
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机译:生物制药和生物分子分析的自由基剂量测定
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摘要
The three-dimensional structural analysis of pharmaceutical and/or biological molecules is performed by the reaction of OH radicals on the surfaces of the molecules of interest. Quantitation and/or completeness of the OH radicals are optionally measured using buffers intrinsic to the sample solutions as internal standards. Measurements of the reactions of these buffers with OH radicals provide an internal standard while avoiding the use of prior art internal standards that can have unwanted effects on the three-dimensional structures of interest.
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