HIERARCHICAL MODEL FOR DETECTING BENIGN AND MALIGNANT DEGREE OF SKIN TUMORS AND APPLICATION THEREOF

摘要

Disclosed are a grading model for detecting the benign and malignant degree of skin tumors and an application thereof. The model grades changes of imprinted genes in tumors by calculating the expression of the loss of imprinting of the imprinted genes, the expression of the copy number variation of the imprinted genes and the total expression of the imprinted genes. The detection model and device intuitively express the presentation of the loss of imprinting on tissue and cell samples of patients with skin tumors, detect the changes of imprinted genes by means of in-situ marking objectively, intuitively and accurately in an early phase, provide a quantitative model, and make a great contribution to the diagnosis of skin tumors.