Small molecule inhibitor of lactate dehydrogenase and its usage

摘要

Provided are compounds of formula (I) (I), wherein Ar1, R1, U, V, W, X and p are as described herein. Methods for treating cancer, methods for treating patients having cancer cells resistant to anticancer agents, and lactate dehydrogenase A (LDHA) and / or lactate dehydrogenase B (LDHB) activity in the cells Also provided are methods of using compounds of formula (I), including methods of inhibiting.